发明名称 |
PROCESS FOR THE PREPARATION OF SPERGUALIN-RELATED COMPOUNDS HAVING A PHENYLENE GROUP |
摘要 |
<p>The present invention reales to novel Spergualin related compounds, and a process for producing the same. More particularly, the invention reales to Spergualin related compounds of the formula: …<CHEM>… wherein R1 is a lower alkylene group which may be substituted by a hydroxymethyl group; X is a hydrogen atom or a halogen alom; m and n are each 0 or an integer of 1 to 5, and salts thereof, as well as a process for producing the compounds of formula (I) and salts thereof by removing the protecting groups from a protected Spergualin related compounds of the formula: …<CHEM>… wherein R1 is a straight chain or branched lower alkylene group which may be substituted by a hydroxymethyl group, the hydroxyl group of which may be protected; R2 is an amino protecting group; R3 is a protected amino group; X, m and n are as defined above. …<??>The compounds of the formula I have anti-tumor activity and can therefore be used as medicaments.</p> |
申请公布号 |
KR910004378(B1) |
申请公布日期 |
1991.06.26 |
申请号 |
KR19850001233 |
申请日期 |
1985.02.27 |
申请人 |
ZAIDAN HOJIN BISEIBUTSU;CHEMICAL INSTITUTE |
发明人 |
UMEJAWA HAMAO;DAKAHASHI KATSUTOSHI;DAKEUCHI TOMIO;NAKAMURA DERUYA;NISHIJAWA LINJO;UMEDA YOSHIHISA |
分类号 |
A61K31/165;A61P31/04;A61P35/00;C07C67/00;C07C239/00;C07C277/08;C07C279/14;C07C279/18;C07D209/48;(IPC1-7):C07C279/04 |
主分类号 |
A61K31/165 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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