发明名称 |
MONOCLONAL ANTIBODY WHICH DISTINGUISHES HELPER INDUCER AND SUPRESSOR INDUCER CE4+ LYMPHOCYTES |
摘要 |
A monoclonal antibody which binds preferentially to a subset of the human CD4+ lymphocyte population whereby to positively and precisely distinguish between helper-inducer and suppressor-inducer cells in the CD4+ cell population. The monoclonal antibody recognizes a novel antigen on the CD4+ lymphocytes by means of which it can bind CD4+ cells which express the antigen on the surface of CD4+ cells. The CD4+ subset cell population to which this antibody preferentially binds is the CD4+ helper-inducer population. This selectivity of the monoclonal antibody enables cell sorting, diagnostic and possible therapeutic applications thereof to be realized. The monoclonal antibody also reacts with CD8 cells, B cells and macrophages. |
申请公布号 |
AU6899491(A) |
申请公布日期 |
1991.06.26 |
申请号 |
AU19910068994 |
申请日期 |
1990.11.15 |
申请人 |
DANA-FARBER CANCER INSTITUTE |
发明人 |
STUART F. SCHLOSSMAN;CHIKAO MORIMOTO |
分类号 |
A61K39/395;A61K38/00;A61K49/00;C07K14/705;C07K16/00;C07K16/28;C07K19/00;C12N5/10;C12N5/20;C12N15/02;C12P21/08;C12R1/91;G01N33/53;G01N33/577 |
主分类号 |
A61K39/395 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|