发明名称 |
ANTIGENS AND POLYPEPTIDES DERIVED FROM BABESIA(12D3 ANTIGEN) |
摘要 |
An antigen inducing protective immunity against homologous or heterologous challenge with Babesia of cattle having the following properties:- (i) one sub-unit having a molecular weight of 38,000; (ii) an N terminus end of the 38,000 molecular weight sub-unit including the sequence Methionine-Tyrosine-Aspartate-Glutamine-Asparagine-Glycine-Lysine; and (iii) another polypeptide having a molecular weight of 22,000 which is bound or associated with the sub-unit of molecular weight 38,000. The invention also includes an antigen obtained from the abovementioned native antigen by recombinant methods having a defined amino acid sequence and an antigen derived from a gene having a defined DNA sequence. THe invention also includes within its scope monoclonal antibodies immunoreactive with these antigens as well as vaccines for treatment of babesiosis also including the above antigens. |
申请公布号 |
ZA9006667(B) |
申请公布日期 |
1991.06.26 |
申请号 |
ZA19900006667 |
申请日期 |
1990.08.22 |
申请人 |
COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION |
发明人 |
PETER WILLIAM RIDDLES;JAMES HARRISON AYLWARD;IAN GORDON WRIGHT |
分类号 |
A61K39/00;C07K14/44;C07K16/20;C12N15/30;C12P21/08 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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