Synthesis of 2,3,5-trisubstituted-2-cyclopentenones via base induced cyclization of alpha-chloro unsaturated ketones

摘要

2,3,5-trisubstituted-2-cyclopentenones or 2,3-disubstituted-2-cyclopentenones (such as cis-jasmone) are prepared by contacting a 3-chloro-3,4-disubstituted-4-pentene-2-one with a strong base. Methods of preparing the reactants are also disclosed.