| 摘要 |
A compound of the chemical formula <IMAGE> wherein n is 1 or 2, X is NH and O, and R1 and R2 are H, (C1-C12) alkyl, (C2-C12)alkenyl, (C2-C12)alkynyl, (C2-C12)acyl, (C6-C12)aryl or (C7-C21)alkylaryl, salts thereof and a composition thereof. In vivo and in vitro methods of inhibiting the growth of a virus relying on the effect of the above compound. In vitro and in vivo methods of inhibiting the growth of the HIV-1 virus comprising administering a compound of the formula <IMAGE> +TR <IMAGE> wherein n is 1 or 2, X is NH or O, and R1 and R2 are independently of one another H, (C1-C12)alkyl, (C2-C12)alkenyl, (C2-C12)alkynyl, (C2-C12)acyl, (C6-C12)aryl or (C7-C21)alkylaryl, R3 is C=N or COR5, wherein R5 is selected from the group consisting of H, (C1-C12) alkyl, alenyl or alkynyl, HO, NH2 and (C2-C12) alkoxy, and R4 is selected from the group consisting of (C1-C12) alkyl, alkenyl or alkynyl and (C2-C12) acyl, and pharmaceutically-acceptable salts thereof, for a period of time effective to attain the desired result to a subject or to cell suspensions infected with the virus.
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