发明名称 |
POLYPEPTIDE OR ITS FRAGMENT, METHOD OF ITS PREPARATION, DNA BASE SEQUENCE, TRANSFORMATION CELL HOST AND PHARMACEUTICAL COMPOSITION CONTAINING POLYPEPTIDE |
摘要 |
Polypeptides, in particular the polypeptide of formula I: Ala-Gln-Glu-Pro-Val-Lys-Gly-Pro-Val-Ser-Thr-Lys-Pro-Gly-Ser-Cys-Pro-Il e-Ile-Leu- Ile-Arg-Cys-Ala-Met-Leu-Asn-Pro-Pro-Asn-Arg-Cys-Leu-Lys-Asp-Thr-Asp-Cy s-Pro-Gly- Ile-Lys-Lys-Cys-Cys-Glu-Gly-Ser-Cys-Gly-Met-Ala-Cys-Phe-Val-Pro-Gln and analogues thereof which possess inhibitory activity against human leukocyte elastase. The polypeptides may be obtained by expression using plasmidic expression systems in hosts such as E. Coli and yeast, the polypeptide of formula I being also obtainable from psoriatic plaques. |
申请公布号 |
JPH03148299(A) |
申请公布日期 |
1991.06.25 |
申请号 |
JP19900148816 |
申请日期 |
1990.06.08 |
申请人 |
IMPERIAL CHEM IND PLC <ICI> |
发明人 |
ENOO KURISUTOFUAASU;ORIBAA UIIDOU;IENSUUMIHIERU SHIYURODAA;MAIKERU DERITSUKU ETSUJI;DEEBITSUDO PIORI |
分类号 |
A61K38/00;A61K38/55;A61P11/00;A61P17/00;A61P37/00;C07K1/20;C07K14/00;C07K14/39;C07K14/435;C07K14/47;C07K14/81;C07K16/00;C07K16/18;C07K16/38;C12N1/19;C12N1/21;C12N9/99;C12N15/09;C12N15/15;C12N15/81;C12P21/02;C12P21/08;C12R1/19;C12R1/865 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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