| 摘要 |
Compounds represented by the general formula: <IMAGE> in which R1 and R2 are selected from hydrogen, C1-C6 alkyl or C2-C6 alkenyl , phenyl or benzyl or R1 and R2 form together with the nitrogen atom to which they are attached a C4-C8 saturated heterocycle, R3 is selected from hydrogen, C1-C6 alkyl, phenyl or C7-C9 phenyl-alkyl, R4 is selected from hydrogen or C1-C4 alkyl, R5 and R6 are selected from hydrogen or halogen, C1-C3 or alkoxy, nitro or trifluoromethyl; Z is selected from OH, C1-C6 alkoxy, C1-C4 alkyl, benzyl, C4-C6 aryl with or without a heteroatom, or NR8R9, R8 and R9 being selected from hydrogen, C1-C4 alkyl, phenyl or benzyl; R10 is selected from hydrogen, C1-C4 alkyl or phenyl; n is 0, 1 or 3, p is 0 or 1 and one of the symbols A, B, C, D represents N and the others CH or A, B, C, D all represent CH and their acid addition salts, and their salts with bases. The compounds are useful in the prevention and treatment of cardiovascular diseases, as anti-allergic drugs, in the prevention and treatment of infectious states, and for the treatment of anxiety.
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