| 摘要 |
PURPOSE:To obtain uniform microcapsules easily in obtaining the microcapsules by utilizing the phase separation of a polymer soluble in the stomach or intestines or both, by incorporating ethyl cellulose as a flocculation inhibitor in a core substance. CONSTITUTION:A core substance, e.g. a medicine, agricultural chemical, cosmetic or food, is dispersed in a solution containing a polymer soluble in the stomach or intestines or both and ethyl cellulose as a flocculation inhibitor. A film of the polymer is formed on the core substance by the phase separation of the polymeric solution to give the aimed microcapsules soluble in the stomach or intestines or both. The amount of the polymer is about 0.02-10, preferably about 0.1-5 times, that of core substance. Thus, the microcapsules having uniform and relatively narrow distribution of the particle size can be obtained with suppressed coagulation of the polymer or mutual flocculation of microcapsules. |
