| 摘要 |
<p>The present invention relates to new racemic and optically active compounds containing a first moiety derived from a pilocarpine compound in which the furanone ring of pilocarpine is replaced by a hetero-ring containing a secondary nitrogen heteroatom, and a second moiety derived from an epinephrine compound or a beta -adrenergic blocking compound, linked at the secondary nitrogen atom of the furanone-replacing hetero-ring of the pilocarpine compound and at the hydroxyl group of the epinephrine compound or of the beta -adrenergic blocking compound, via a carbonyl linker, and pharmaceutically acceptable acid addition salts thereof. The new compounds of the present invention are potent ocular hypotensives exhibiting minimal deleterious pupillary effects.</p> |
