Cycloheptimidazolone compounds as angiotensin II antagonists for control of hypertension.

摘要

A class of cycloheptimidazolone compounds is described as angiotensin II antagonists for use in control of hypertension. Compounds of particular interest are those of the formula <CHEM> wherein each of R<1> and R<2> is independently selected from hydrido, alkyl, halo, alkanoyl, carboxyl, alkoxycarbonyl, phenyl, haloalkyl, alkoxyalkyl, formyl, cyano, alkoxy, phenoxy, phenylthio, alkylthio; wherein R<3> is alkyl,alkenyl, alkynyl, hydroxyalkyl and alkoxyalkyl; wherein each of R<5> through R<1><3> is independently selected from hydrido, alkyl, haloalkyl, halo, nitro, cyano, hydroxy, alkoxy, alkylthio, aryl, aryloxy, arythio, and acidic groups such as carboxylic acid, with the proviso that at least one of R<9> through R<1><3> substituents is an acidic group; or a pharmaceutically-acceptable ester, amide or salt thereof.