The invention concerns novel renin-inhibitory peptides which are useful for treating renin-assocated hypertension, hyperaldosteronism, and congestive heart failure. Processes for preparing the peptides, compositions containing them and methods of using them are included. Also included is a diagnostic method which uses the compounds to determine the presence of renin-associated hypertension or hyperaldosteronism.
申请公布号
US5024994(A)
申请公布日期
1991.06.18
申请号
US19880233320
申请日期
1988.08.17
申请人
WARNER-LAMBERT COMPANY
发明人
DOHERTY, ANNETTE M.;HUDSPETH, JAMES P.;KALTENBRONN, JAMES S.;REPINE, JOSEPH T.;ROARK, WILLIAM H.;SIRCAR, ILA;TINNEY, FRANCIS J.