ALTERATION OF ABILITY OF SOLUBLE CD4 PROTEIN TO BIND CLASS II MHC ANTIGENS

摘要

ALTERATION OF ABILITY OF SOLUBLE CD4 PROTEIN TO BIND CLASS II MHC ANTIGENS The present invention pertains to biologically active, modified soluble human CD4 surface glycoprotein fragments having a decreased affinity (compared to naturally occurring human CD4) for major histocompatibility class II antigens but which are capable of binding to the HIV gp120 envelope protein. The soluble CD4 fragments have the ability to inhibit HIV binding to naturally occurring CD4 surface receptors but will not inhibit class II MHC recognition events.