| 摘要 |
Alkylamino- and alkylaminoalkyl diarylketones, a process for their preparation and their use as medicaments This invention relates to alkylamino and alkyl amino alkyl diarylketones of the formula where Ar is aryl of the formula , where V is hydrogen, halogen, loweralkyl, loweralkoxy, CF3, NO2 and u is an integer of 1 to 3; X and Y are independently CH2-, -CF2- or -CHF-; Z and W are independently -CH2, -O-, -CHOH-, or -CHF-; m, n, p, q and t are integers which are independently 0 or 1; R1 is H or loweralkyl; R2 and R3 are loweralkyl; and the pharmaceutically acceptable acid addition salts thereof and where applicable the geometric and optical isomers and racemic mixtures thereof. The compounds of this invention display utility as analgesic agents and as agents for alleviating various memory dysfunctions, characterized by a decreased cholinergic function, such as Alzheimer's disease.
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