发明名称 |
TREATMENT OF HSV |
摘要 |
Basic fibroblast growth factor, a 146 amino acid residue polypeptide, analogs thereof, a lectin, suramin, protamine and/or a shortened fragment of either bFGF or of an analog thereof is used to prevent the spread of HSV-1. It has been found that topical application of an effective amount of such an agent prevents HSV uptake and/or infection in cells that are otherwise targets for such virus. One group of preferred agents are peptides which include the decapeptide sequence of a mammalian bFGF(106-115), e.g., bovine bFGF(106-115), examples of such preferred peptides include bovine bFGF(103-120)-NH2 and human bFGF(103-120)-NH2. |
申请公布号 |
WO9107982(A1) |
申请公布日期 |
1991.06.13 |
申请号 |
WO1990US06962 |
申请日期 |
1990.11.29 |
申请人 |
THE SALK INSTITUTE FOR BIOLOGICAL STUDIES;CORNELL RESEARCH FOUNDATION, INC. |
发明人 |
BAIRD, JACQUES, ANDREW, CLOUTIER;HAJJAR, DAVID, PHILLIP |
分类号 |
A61K31/185;A61K38/00;A61K38/16;C07K14/50 |
主分类号 |
A61K31/185 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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