| 摘要 |
Compounds of formula (I) are diuretic agents for treating various cardiovascular diseases including hypertension, heart failure and renal insufficiency. Formula (I), wherein A completes a 4-to-7-membered saturated or unsaturated carbocyclic ring optionally fused to a further saturated or unsatured 5-or-6-membered carbocyclic ring, R and R<4> are H, C1-C6 alkyl, benzyl or a biolabile ester-forming group, R1 is H or C1-C4 alkyl, R<2>, R<3>, R<18> and R<19> are H, C1-C6 alkyl, C1-C4 alkoxy, aryl (C1-C6) alkyl, aryl (C2-C6) alkenyl, aryl (C1-C6) alkoxy (C1-C4) alkyl or hydroxy (C1-C4) alkyl, or R<2> and R<18> form 2-indanylidene, and R<5> includes a range of alkyl, alkenyl, alkynyl, cycloalkyl, cylcloalkenyl and substituted alkyl including S-lysylaminomethyl, N<2>-acetyl-S-lysylaminomethyl and N<2>-methanesulphonyl-S-lysylaminomethyl. |
