发明名称 |
ANTIBODY VARIABLE DOMAIN CONJUGATES |
摘要 |
Small specific binding molecules, such as single variable domain antibodies (Dabs) and Fv fragments, can be coupled to solid plastics surfaces or to tracers such as enzymes by means of linkers comprising polypeptides containing from 5 to 20 amino acids and which are hydrophobic and/or contain at least one lysine residue. The coupling can be achieved without significant loss of specific binding activity. The combined Dab/linker or Fv/linker can be prepared by expression in genetically-modified organisms. |
申请公布号 |
WO9108482(A1) |
申请公布日期 |
1991.06.13 |
申请号 |
WO1990GB01839 |
申请日期 |
1990.11.27 |
申请人 |
UNILEVER PLC;UNILEVER NV |
发明人 |
DAVIS, PAUL, JAMES;VERHOEYEN, MARTINE, ELISA;DE WINTER, RONALD, FRANKS, JACABUS |
分类号 |
G01N33/535;C07K7/06;C07K16/00;C07K16/40;C07K16/44;C07K19/00;C12N9/08;C12N9/16;C12N15/62;G01N33/532;G01N33/543;G01N33/547;G01N33/68 |
主分类号 |
G01N33/535 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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