| 摘要 |
<p>A decapeptide of the amino acid sequence: H-X1-Leu-Thr-Ile-Asp-Lys-Lys-Gly-Thr-Gly-Ala-X2-Y where X?1 and X2¿ each represent an optional coupling-facilitating amino acid residue and Y represents -NH¿2? or -OH, is disclosed. Also disclosed are monoclonal antibodies specifically binding to only one epitode of Lys?342¿-α¿1?-antitrypsin, i.e. Z-protein, comprising Lys?342¿; a hybridoma cell line producing said monoclonal antibodies; and a method for preparing the hybridoma cell line. Further disclosed are a method for in vitro diagnosis of α¿1?-antitrypsin deficiency, i.e. the presence in the blood of Lys?342¿-α¿1?-antitrypsin, in man, and an immunoassay kit for said diagnosis.</p> |
