METHOD OF PREVENTING OR LIMITING REPERFUSION DAMAGE

摘要

The use of an N-alkylpiperazinealkanamide for preventing and/or limiting reperfusion damage upon reperfusion of an organ or muscular tissue, particularly in a patient undergoing thrombolysis or reperfusion of the heart after open heart surgery or after receiving a donor heart. The use of an N-alkylpiperazinealkanamide for preventing and/or limiting reperfusion damage upon reperfusion of a transplanted heart. The use of an N-alkylpiperazinealkanamide for storing a heart for transplantation for at least 24 hours in a cold cardioplegic solution. Compositions comprising an effective reperfusion damage preventing and/or limiting amount of an N-aryl-piperazinealkanamide derivative and optionally further comprising a thrombolytic agent and/or cyclodextrin or an ether derivative thereof. Processes for preparing such compositions. Novel N-alkylpiperazinealkanamide compounds and a process for preparing said compounds.