| 摘要 |
<p>Compounds of formula (I) are diuretic agents for treating various cardiovascular diseases including hypertension, heart failure and renal insufficiency. Formula (I), wherein A completes a 4-to-7-membered saturated or unsaturated carbocyclic ring optionally fused to a further saturated or unsatured 5-or-6-membered carbocyclic ring, R and R4 are H, C¿1?-C6 alkyl, benzyl or a biolabile ester-forming group, R1 is H or C1-C4 alkyl, R?2, R3, R18 and R19¿ are H, C¿1?-C6 alkyl, C1-C4 alkoxy, aryl (C1-C6) alkyl, aryl (C2-C6) alkenyl, aryl (C1-C6) alkoxy (C1-C4) alkyl or hydroxy (C1-C4) alkyl, or R?2 and R18¿ form 2-indanylidene, and R5 includes a range of alkyl, alkenyl, alkynyl, cycloalkyl, cylcloalkenyl and substituted alkyl including S-lysylaminomethyl, N2-acetyl-S-lysylaminomethyl and N2-methanesulphonyl-S-lysylaminomethyl.</p> |
