RRNA SPECIFIC OLIGONUCLEOTIDES

摘要

The present invention relates to a method of inhibiting protein synthesis comprising contacting 28S rRNA of a protein synthesizing system with a protein synthesis inhibitory amount of an oligonucleotide that hybridizes to the -sarcin recognition domain loop of said 28S rRNA under condition such that hybridization occurs. The invention also relates to oligonucleotides suitable for use in such a method.