CATECHOLAMINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THEREOF

摘要

There are described compounds of formula I, I in which X represents a C2 to 8 alkylene chain optionally interrupted by a double bond or by S(O)n, wherein n is 0, 1 or 2; Y represents O or NH, l and m each independently represent 2, 3 or 4, R10 represents phenyl substituted by one or more substituents R23, which may be the same or different; or R10 represents pyridyl, a saturated carbocyclic group, alkyl C 1 to 6 or hydrogen, R15 represents hydrogen or together with R23 forms a (CH2)p chain, wherein p represents 0, 1 or 2; R20, R21, R22 and R23, which may be the same or different, independently represent hydrogen, alkyl C 1 to 6, NHR25, SH, NO2, halogen, CF3, SO2R30, CH2OH or OH, wherein R25 represents hydrogen, alkyl C 1 to 6, alkanoyl C 1 to 6 or SO2 alkyl C 1 to 6, and R30 represents alkyl C 1 to 6 or NH2, provided that when X represents an uninterrupted C4 alkylene chain, Y represents NH, m represents 2, l represents 2, R10 represents phenyl, R15 represents hydrogen, and R21, R22 and R23 represent hydrogen, then R20 does not represent hydrogen or 4-OH, and pharmaceutically acceptable salts and solvates thereof. There are also described processes for the preparation of the compounds of formula I and pharmaceutical compositions containing them. The compounds of the invention may be used in the treatment or prophylaxis of renal failure or cardiovascular disorders.