| 摘要 |
PURPOSE:To easily fix antigen and antibody by synthesizing ferrite by coprecipitation method in ribosome produced in a water-base medium, comprising double-lipid layer phosphatide containing bonding functional groups. CONSTITUTION:In a water-base medium, there are dispersed (A)0.2 mg/ml phosphatide having bonding functional groups such as amino groups and COOH groups (e.g. phosphadiethanol amine), (B)0.01 - 1.0 mol bivalent metal salt (e.g. FeCl2 4H2O), and (C)0.01 - 1.0 mol trivalent iron sat (e.g. FeCl3) with (B)/(C) molar ratio of about 1/2. Ribosome comprising double-lipid layer of the component (A) is produced, and then metal ions existing in the medium out of the ribosome is removed. The medium is maintained at pH>=11, more desirably at pH>=12 to effect the reaction of (B) and (C) to produce ribosome containing ferrite (precursol) coprecipitate. Then the ribosome is separated from the medium, gel-filtered to obtain a uniform size, and freeze-dried. Thus, fine particles of ferrite covered with the component (A) having 80 - 200 Angstrom particle size can be obtained. |
