Isolation and structural elucidation of the cyclic peptide hymenistatin 1.

摘要

A new and demonstratably active cyclo-octapeptide is isolated from the South Pacific Ocean Hymeniacidon sp. and structurally elucidated. The substance, herein denominated Hymenistatin 1, demonstrated utility by inhibiting tumor growth when measured by the National Cancer Institute P388 leukemia cell line (ED50 = 3.5 mu g/mL). Hymenistatin 1 has the following structure: