摘要 |
<p>Process for preparing monhydrate 7-(D-2-amino-phenylacetamido)-3-chloro-3-cefem-4-carboxilic acid, comprising the condensation between silanized 7-amino-3-chloro-cephalosporanic acid and D(-)-phenylglycine chloride hydrochloride in the presence of a proton acceptor, such condensation yields a product which precipitates in form of solvate of acetonitrile, from which the final product is obtained by known techniques, said process allowing to obtain higher yields and a purer product.</p> |