| 摘要 |
TITLE: PURIFICATION OF 5-PYRIMIDINECARBOXAMIDES A process is provided for the purification to highly purified states of 5-Pyrimidinecarboxamides which are essentially insoluble in both organic and inorganic solvents. The 5-Pyrimidinecarboxamide to be purified is contacted with an organic base to form an adduct. The adduct is purified through recrystallization and the desired 5-Pyrimidinecarboxamide is regenerated from the adduct in highly purified form with acid. Additionally, an adduct resulting from the combination of a 5-Pyrimidinecarboxamide with an organic base is provided, which adduct is capable of being purified using recrystallization techniques, where the 5-Pyrimidine-carboxamide is not itself capable of being so purified due to its relative insolubility in organic and inorganic solvents. The 5-pyrimidinecarbonamides exhibit antileukemia and anti-tumor activity.
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