| 摘要 |
Compounds of the general formula: <IMAGE> and physiologically acceptable salts, and hydrates, N-oxides and bioprecursors of such compounds and such salts in which R1 and R2, which may be the same or different, represent hydrogen or lower alkyl, cycloalkyl, aralkyl or lower alkenyl groups, or lower alkyl groups interrupted by an oxygen atom or a group <IMAGE> in which R4 represents hydrogen or lower alkyl; or R1 and R2 may, together with the nitrogen atom to which they are attached form a heterocyclic ring which may contain the hetero functions -O- and <IMAGE> R3 represents hydrogen, lower alkyl, alkenyl or alkoxyalkyl; X represents -O-, -S- or -CH2- or <IMAGE> where R5 is hydrogen or lower alkyl; Y represents =S, =O, =NR6 or =CHR7; in which R6 represents hydrogen, nitro, cyano, lower alkyl, aryl, arylsulphonyl or lower alkylsulphonyl; R7 represents nitro, lower alkylsulphonyl or arylsulphonyl; m is an integer from 2 to 4 inclusive; n is zero, 1 or 2; and Alk denotes a straight or branched alkylene chain of 1 to 6 carbon atoms. The compounds have therapeutic activity.
|
