Angiostatic collagen modulators

摘要

Angiostatic compounds are potentiated by collagen matrix metabolism modulators including: a) proline analogs which inhibit proline hydroxylation when substituted for proline in collagen; b) inhibitors of proline hydroxylase; c) inhibitors of collagen cross-linking; and d) all trans-retinoic acid. In methods and therapeutic compositions for inhibiting angiogenesis in a mammal, the collagen matrix modulator is administered with an angiostatic steroid or with heparin (including angiostatic heparin fragments of six or more sugar units, and synthetic fragments).