| 摘要 |
<p>Rana pipiens eggs are subjected to fertilization and the embryos are grown to a predetermined stage of development. The embryos and unfertilized eggs are then subjected to mechanical processing in the presence of a weakly acidic buffer to produce an extract. The extract is subjected to ion-exchange chromatography and size-exclusion chromatography. The resulting pharmaceutical has activity against certain cancer cells. The amino acid sequence and composition of the pharmaceutical are disclosed. When the pharmaceutical is combined with other drugs sold under the trademarks TAMOXIFEN and STELAZINE, the combination with TAMOXIFEN has unexpected bioactivity in vitro against ASPC-1 human pancreatic adenocarcinoma cells and the combination with STELAZINE has unexpected bioactivity in vitro against A-549 human lung carcinoma cells.</p> |
