LOCALIZATION AND CHARACTERIZATION OF THE WILMS'S TUMOR GENE

摘要

The Wilms's tumor gene associated with 11p13 locus on the human chromosome, as well as a method of analyzing cells for the gene is described and characterized. The gene encodes a transcription unit approximately 50 kb in size and an mRNA of approximately 3 kb, which is expressed in a limited number of cell types (e.g, predominantly kidney cells and a subset of hematopoietic cells). The polypeptide encoded by the Wilms' tumor DNA includes four "zinc fingers" and a region rich in proline and glutamine, suggesting that the polypeptide has a role in transcription regulation.