| 摘要 |
<p>A method of enhancing in vivo melanin production is disclosed. The method comprises topically applying an effective amount of at least one Protein Kinase C Activator to the surface of the skin. Also disclosed is a composition for enhancing in vivo melanin production. The composition comprises an effective amount of at least one Protein Kinase C Activator in combination with at least one physiologically acceptable solvent. The composition may optionally contain at least one other ingredient selected from the group consisting of: riboflavin, riboflavin phosphate, mixtures of riboflavin and riboflavin phosphate, DOPA phosphates, sunscreening agents, emollients, emulsifiers, solvents for sunscreening agents, waxes, thickeners, film formers, humectants, antioxidants, preservatives, surfactants, perfumes, biological additives, buffering agents, chelating agents, emulsion stabilizers, opacifying agents, pH adjusters, propellants and coloring agents. The Protein Kinase C Activators in the methods and compositions of this invention can be selected from the group consisting of: diacylglycerols, triacylglycerols, lipopolysaccharides, unsaturated free fatty acids, saturated short chain free fatty acids, glycerolphospholipids, enzymes which hydrolyze glycophospholipids to diacylglycerols, and bryostatins.</p> |
