CHIMERIC PROTEINS

摘要

2069106 9107979 PCTABS00005 A chimeric peptide is provided which includes at least a portion of the B subunit of cholera toxin and an epitope region of a desired antigen fused to the N-terminal end of the B subunit of cholera toxin. The epitope region includes an antigenic determinant of the desired peptide. According to certain preferred embodiments, such chimeric peptides are used as a vaccine to elicit an immune response in a subject to a desired antigen. Recombinant-DNA mediated methods for the production of a chimeric peptide, DNA sequences, vectors and host organisms used in such methods are also provided.