发明名称 |
METHOD OF DETECTING SPECIFIC BINDING SUBSTANCES IN BODY FLUIDS |
摘要 |
To detect specific binding substances in body fluids by the immunoassay principle using ligand conjugates for the labelling, immobilisation or complexation, which contain in free form the ligands used for the ligand conjugates, the ligands which are present in free form are removed from the immunological reaction by incubating the sample solution with polymer particles consisting of core and coating, which have as core a polymer which has a plurality of binding sites for the ligand and as coating at least one layer of protein, peptide, nucleic acid polymer, carbohydrate and/or a copolymer of carbohydrate and amino acids, where the layer thickness of the coating is adjusted so that the coating is permeable to the free ligand but not to the ligand conjugate. …<IMAGE>… |
申请公布号 |
EP0397113(A3) |
申请公布日期 |
1991.05.29 |
申请号 |
EP19900108656 |
申请日期 |
1990.05.08 |
申请人 |
BOEHRINGER MANNHEIM GMBH |
发明人 |
OFENLOCH-HAEHNLE, BEATUS, DR.RER.NAT.;BERGER, MICHAEL, DR.RER.NAT.;DEGER, ARNO, DR.RER.NAT. |
分类号 |
G01N33/531;G01N33/538;G01N33/543;G01N33/544;G01N33/546;G01N33/548;G01N33/573;(IPC1-7):G01N33/544 |
主分类号 |
G01N33/531 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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