发明名称 MELPHALAN DERIVATIVES
摘要 A compound of formula I Formula I wherein R1 is of formula II Formula II wherein R4 and R5 , which may be the same or different, are bromo, chloro, iodo or alkylsulphonyl: R2 is of formula III Formula III wherein R6 and R7 , which may be the same or different, are H, alkyl, aryl, carboxy, hydroxy or amino and n is 0-10; and R is hydroxy or a group capable of being cleared and replaced by a radical having an antigen binding site or is a radical having an antigen binding site. Compounds of the present invention are useful as antitumor agents.
申请公布号 CA1284507(C) 申请公布日期 1991.05.28
申请号 CA19860526567 申请日期 1986.12.31
申请人 UNIVERSITY OF MELBOURNE (THE) 发明人 MCKENZIE, IAN F.C.;PIETERSZ, GEOFFREY A.;SMYTH, MARK
分类号 C07K14/00;A61K39/00;A61K47/48;C07C67/00;C07C231/00;C07C231/02;C07C231/12;C07C233/47;C07C233/51;C07C235/12;C07C237/12;C07C313/00;C07C317/28;C07K1/113;C07K5/06;C07K19/00 主分类号 C07K14/00
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