发明名称 |
Very low temperature casting of controlled release microspheres |
摘要 |
A process for preparing microspheres using very cold temperatures to freeze polymer-biologically active agent mixtures into polymeric microspheres with very high retention of biological activity and material. Polymer is dissolved in a solvent together with an active agent that can be either dissolved in the solvent or dispersed in the solvent in the form of microparticles. The polymer/active agent mixture is atomized into a vessel containing a liquid non-solvent, alone or frozen and overlayed with a liquified gas, at a temperature below the freezing point of the polymer/active agent solution. The cold liquified gas or liquid immediately freezes the polymer droplets. As the droplets and non-solvent for the polymer is warmed, the solvent in the droplets thaws and is extracted into the non-solvent, resulting in hardened microspheres.
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申请公布号 |
US5019400(A) |
申请公布日期 |
1991.05.28 |
申请号 |
US19890346143 |
申请日期 |
1989.05.01 |
申请人 |
ENZYTECH, INC. |
发明人 |
GOMBOTZ, WAYNE R.;HEALY, MICHAEL S.;BROWN, LARRY R. |
分类号 |
A61K9/14;A61K9/16;A61K9/58;A61K47/32;A61K47/34;B01J2/06;F26B3/12;F26B5/00;F26B5/06;F26B7/00 |
主分类号 |
A61K9/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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