摘要 |
The invention provides compounds of the general formula (I): <CHEM> or a physiologically acceptable salt or a solvate (e.g. hydrates) thereof in which R<1> represents a hydrogen atom or a halogen atom or a group selected from C1-6 alkyl, C2-6 alkenyl, fluoroC1-6alkyl, -CHO, -CO2H or -COR<4>; R<2> represents a hydrogen atom or a halogen atom or the group Ar; R<3> represents a hydrogen atom or a group selected from C1-6 alkyl, C3-6alkenyl, C1-6alkoxy, -COR<4>, -SO2R<4> or the group Ar; R<4> represents a group selected from C1-6 alkyl, C2-6 alkenyl, C1-6 alkoxy or the group -NR<1><2>R<1><3>; Ar represents the group <CHEM> R<5> represents a group selected from -CO2H, -NHSO2CF3 or a C-linked tetrazolyl group; R<6> and R<7> which may be the same or different each independently represent a hydrogen atom or a halogen atom or a C1-6alkyl group; Het represents an N-linked imidazolyl group substituted at the 2-position by a C1-6alkyl, C2-6alkenyl or a C1-6alkylthio group, the imidazolyl group optionally being substituted by one or two further substituents selected from a halogen atom or a group selected from cyano, nitro, C1-6alkyl, C2-6alkenyl, fluoroC1-6alkyl, -(CH2)mR<8>, -(CH2)nCOR<9>, or -(CH2)pNR<1><0>COR<1><1>; or Het represents an N-linked benzimidazolyl group substituted at the 2-position by a C1-6alkyl, C2-6alkenyl or a C1-6alkylthio group; R<8> represents a hydroxy or C1-6alkoxy group; R<9> represents a hydrogen atom or a group selected from hydroxy, C1-6alkyl, C1-6alkoxy, phenyl, phenoxy or the group -NR<1><2>R<1><3>; R<1><0> represents a hydrogen atom or a C1-6alkyl group; R<1><1> represents a hydrogen atom or a group selected from C1-6alkyl, C1-6alkoxy, phenyl, phenoxy or the group -NR<1><2>R<1><3>; R<1><2> and R<1><3> which may be the same or different each independently represent a hydrogen atom or a C1-4alkyl group or -NR<1><2>R<1><3> forms a saturated heterocyclic ring which has 5 or 6 ring members and may optionally contain in the ring one oxygen atom; m represents an integer from 1 to 4; n represents an integer from 0 to 4; and p represents an integer from 1 to 4; provided that one of R<2> and R<3> represents the group Ar, and that when R<2> represents the group Ar, R<3> represents a hydrogen atom or a group selected from C1-6 alkyl, C3-6 alkenyl, C1-6alkoxy -COR<4> or -SO2R<4>, and that when R<3> represents the group Ar, R<2> represents a hydrogen atom or a halogen atom. The compounds may be used in the treatment or prophylaxis of hypertension and diseases associated with cognitive disorders. |