| 摘要 |
<p>I pyrrolidines (I) where R = H, (1-4C) alkyl, (1-4C) alkanoyl R' = (2-4C) alkyl. II Acid addn. salts and pharm. prepns. of I. Analgesics with no side effects, and no tendency to addiction. 2-(m-methoxyphenyl)-alpha-propylsuccinonitrile (23 g.), Raney nickel (6 g.) and MeOH (150 ml.) stirred in an autoclave at 126 kg./cm2, heated to 170 deg.C, the pressure rising to 168 kg./cm2, and kept there until H2 adsorption ceased. Cooled, filtered, evapd., extd. residue with 2N-HCl, basified, extd. (Et2O), evapd., and distilled at 118-121 deg.C/1 mm., giving 1-methyl-3-(m-methoxyphenyl)-3-propyl-pyrrolidine. Base in Et2O, treated with HCl in PriOH, gave the hydrochloride, m.p. 133-5 deg.C (recryst. from PriOH-Et2O).</p> |
