CHIRAL ORGANOMETALLIC COMPLEXES AND USES THEREOF

摘要

Compounds having general formula (I) wherein (i) Cp is either a cyclopentadienyl ligand having the formula C5(R3)5 where the R3 groups are independently hydrogen, methyl or ethyl or an indenyl ligand; (ii) Z is a ligand having the formula X(R4)2(Y) wherein X is selected from phosphorus, arsenic or antimony; the R4 groups are independently aryl or aroxy and Y is selected from -R5-NHR5 and -OR5 wherein R5 is a hydrocarbyl group; (iii) the R groups are independently hydrogen, halogen or C¿1? to C4 alkyl; (iv) R?1¿ is selected from hydrogen, C¿1? to C6 alkyl, benzyl and -CO2R?6¿ where R6 is C1 to C6 alkyl; (v) R2 is selected from hydrogen, C¿1? to C10 alkyl, phenyl and benzyl, and (vi) B is either R or COY wherein Y is selected from -NHR?7, -OR7¿ and -SR7 where R7 is a hydrocarbyl group is provided. The compounds are efficient asymmetric hydrogenating agents for prochiral carbonyl containing compounds when used in single enantiomer form.