AMMIDI CON AMMINOACIDI NATURALI DI ALCANOIL L-CARNITINE QUALI INIBITORI DELLA DEGENERAZIONE NEURONALE E ATTIVATORI DEI PROCESSI DI APPRENDIMENTO E MEMORIZZAZIONE E PER IL TRATTAMENTO DEL COMA E COMPOSIZIONI FARMACEUTICHE COMPRENDENTI TALI COMPOSTI.

摘要

Amides of alkanoyl L-carnitines of general formula (1). wherein R is a straight or branched alkanoyl group having from 2 to 8 carbon atoms selected from acetyl, propionyl, butyryl, isobutyryl, valeryl, isovaleryl, hexanoyl, 1-methylbutyryl, t-butylacetyl, 2-ethylbutyryl, 3-methylvaleryl, 4-methylvaleryl, 2-ethylhexanoyl and 2-propylpentanoyl; R' is the monovalent residue of a naturally occurring aminoacid selected from: and X<-> is the anion of a pharmacologically acceptable acid are active in regenerating the nervous tissue, inhibiting neuronal degeneration, enhancing the processes of learning and memory and for the treatment of coma. Orally or parenterally administrable compositions in unit dosage form comprise between about 50 and about 500 mg of an amide of formula (1).