| 摘要 |
A method for synthesizing D-alpha-amino acids by contacting under reaction conditions an alpha-keto acid corresponding to the D-alpha-amino acid, and a source of an amino group comprising an L-alpha amino acid or a DL-alpha-amino acid mixture, i.e., a racemic mixture of an amino acid, in the presence as catalyst of D-amino acid transaminase is disclosed and claimed. The method can be under batch or continuous conditions, including means for driving equilibria towards production of the D-alpha-amino acid, such as causing a reduction in the concentration of alpha-keto acid corresponding to the source of amino group by adding to the reaction medium a consumer thereof, e.g., NADH and lactate dehydrogenase, or by a physical separation. |
