| 摘要 |
[(5-oxo-2-pyrrolidinyl)methyl]cyclohexaneacetamides of the formula <IMAGE> I wherein R1 is hydrogen, lower alkyl or aryl-lower alkyl; R2 is hydrogen, lower alkyl, aryl, aryl-lower alkyl, <IMAGE> wherein R5 and R6 are hydrogen, lower alkyl or aryl-lower alkyl; R3 and R4, independently, are hydrogen, lower alkyl, or aryl-lower alkyl; and enantiomers, diastereomers, and racemates thereof, and, when R2 is <IMAGE> pharmaceutically acceptable acid addition salts thereof, are described. The compounds of formula I exhibit cognitive enhancement and antiamnestic activity and are therefore useful, for example, in treating memory deficits associated with Alzheimer's disease or age-associated memory impairment.
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