| 摘要 |
NEW MATERIAL:Compounds of formula I [X is N or CH: R<1> is H, CH3, C2H5 or R<4>CO- (R<4> is H, 1-3C alkyl or furil) in case of X=N and OH or -OR<5> (R<5> is 1-3C alkyl) in case of X=CH; R<2> is H or NO2; R<3> is CN or CONH2] or salts thereof. USE:A cardiotonic and an intermediate of organic compounds. PREPARATION:A compound of formula II is reacted with cyano acetic acid, acetonitrile or malonic acid monoamide in the presence of an acid (e.g. sulfuric acid, benzenesulfonic acid or BF3) or a base (e.g. ammonia, piperidine, NaOH or NaH) or without using a catalyst to obtain the objective compound of formula I. |
