METHOD OF VACCINE OR TOXOID PREPARATION AND IMMUNIZATION BY COLONIZATION WITH RECOMBINANT MICROORGANISMS

摘要

2072657 9106654 PCTABS00005 A method of vaccine or toxoid preparation and immunization against pathogenic disease. An area of the body is colonized with indigenous microorganisms that have been transformed by recombinant DNA technology to express pathogenic antigens. The colonized transformant microorganisms will replicate and elicit an immune response to the pathogenic antigen, thereby protecting the individual from subsequent exposure to the intact pathogen.