CONDENSED IMIDAZOLE DERIVATIVES AND PROCESSES FOR PREPARATION THEREOF

摘要

There are described compounds of the formula: wherein R1 is lower alkyl, halo(lower)alkyl, cyclo(lower)alkyl or lower alkylthio, R2 is hydrogen or imino-protective group, R3 is hydrogen or halogen, A is lower alkylene, and is a group of the formula : , or in which X1, X2, X3 and X4 are each N or CR4, in which R4 is hydrogen, lower alkyl, lower alkoxy, halogen, halo(lower)alkyl, esterified carboxy, halo(lower)alkoxy or hydroxy, provided that at least one of X1, X2, X3 and X4 is N, and pharmaceutically acceptable salts thereof. These compounds are useful as potent and selective antagonists of angiotensin II receptor and can be used as therapeutical and/or preventive agents for cardiopathy (e.g. angina pectoris, arrhythmia, miocardial infarction, etc.) hyperaldosteronism cerebral vascular diseases, senile dementia, ophthalmic diseases (e.g.) glaucoma, etc.), and the like, as well as diagnostic agents for testing the renin angiotensin system. The preparation of these compounds , pharmaceutical compositions containing them, the medical treatment or prevention of angiotensin II mediated diseases, hypertension or heart failure using these compounds are also disclosed.