| 摘要 |
<p>Semisynthetic cephalosporins of the formula: <IMAGE> wherein R is a hydrogen atom or a Cl-(CH2)3-CO-, Ph-CH2-O-CO- or Cl3C-CH2-O-CO- group or other amino protecting group and R' is a hydrogen atom or a Cl3-C-CH2- or CH(C6H5)2- group or other carboxy protecting group, are made by reacting an N-protected alpha-phenylglycine of the formula: <IMAGE> with an N-chlorocarbonyl-sec.amide or lactam of the formula: <IMAGE> wherein X is a bis(mono-C1-C6-alkyl) group, a C1-C6-alkyl diradical, a C1-C4- alkyl diradical containing a hetero-atom selected from N, O and S or a <IMAGE> group, wherein Y is a C1-C6 group or a C0-C4 group containing a heteroatom selected from N, O and S and n is an integer from 0 to 3, and subjecting the resultant mixed anhydride to selective aminolysis with an ester of 7- aminodeacetoxy-cephalosporanic acid. The final products are antibacterial agents or intermediates for their synthesis.</p> |
