发明名称 Antihypercholesterolemic alkylene compounds
摘要 Compounds of the formula <IMAGE> I wherein R1, R2, R3 and R4 each are independently hydrogen, halogen, C1-4 alkyl, C1-4 alkoxy or trifluoromethyl; R is C1-7 alkyl, C3-6 cycloalkyl, fluoromethyl, difluoromethyl, trifluoromethyl; A is <IMAGE> R5 is hydrogen, a hydrolyzable ester group or a cation to form a non-toxic pharmaceutically acceptable salt, are novel antihypercholesterolemic agents which inhibit cholesterol biosynthesis. Intermediates and processes for their preparation are disclosed.
申请公布号 US5011947(A) 申请公布日期 1991.04.30
申请号 US19900538583 申请日期 1990.06.12
申请人 BRISTOL-MYERS 发明人 CATT, JOHN D.;WRIGHT, JOHN J.
分类号 C07C25/24;C07C45/27;C07C45/29;C07C45/30;C07C45/51;C07C47/24;C07C59/56;C07C69/732;C07D309/30;C07F9/40 主分类号 C07C25/24
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