发明名称 |
Synthesis of mannojirimycin derivatives |
摘要 |
alpha -Homojirimycin and 6-dpi-homojirimycin are each synthesized from 2-azido-2-deoxy-3,4:6,7-di-O-isopropylidene-D-glycero-D-talo-heptono-1 ,5-lactone in which the side chain acetonide is hydrolyzed to give the corresponding diol which is then protected with a silyl protecting agent to form a silyl ether. The latter compound is used as a divergent intermediate in which the piperidine ring is formed by joining the nitrogen function at C-2 to C-6 (A) with inversion of configuration at C-6 to form 6-epi-homomannojirimycin or (B) with retention of configuration at C-6 to form alpha -homomannojirimycin.
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申请公布号 |
US5011929(A) |
申请公布日期 |
1991.04.30 |
申请号 |
US19890419806 |
申请日期 |
1989.10.11 |
申请人 |
MONSANTO COMPANY |
发明人 |
FLEET, GEORGE W. J.;BRUCE, IAN |
分类号 |
C07D211/46;A61K31/00;A61K31/445;A61P3/00;A61P3/06;A61P3/08;C07D487/04;C07D491/22;C07D493/04;C07D498/18;C07F7/10;C07F7/18 |
主分类号 |
C07D211/46 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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