PROCESS FOR PRODUCING NEW ARYLOXY-ALCOYL-BENZENES AND PHARMACEUTICAL PREPARATIVES CONTAINING THESE COMPOUNDS

摘要

The invention relates to new aryloxyalkylbenzenes, to processes for their preparation and also to pharmaceutical compositions containing them. It relates more especially to new phenoxyethylbenzenes substituted on either ring, and specifically substituted phenoxyethylbenzenes of general formula I in which Ar is a hydroxylated mono- or bicyclic aromatic radical chosen from among the benzene derivatives of formula in which X represents a hydroxyl which is free, esterified with a carboxylic acid or a sulphonic acid, with phosphoric acid or with sulphuric acid or etherified with a lower alkyl or a lower alkenyl Z is a substituent chosen from the group consisting of hydrogen, halogens, a hydroxyl, a lower alkoxy, an acyloxy, a phenyl(lower) alkyl, a lower alkyl, a lower alkyl substituted with a (lower alkyl)oxycarbonyl or with a hydroxycarbonyl, a chain CO(CH2)mCH3 in which m represents an integer ranging from 1 to 4, a chain CHOH-(CH2)m'CH3 in which m' represents an integer varying from 1 to 4, a phenyl, a phenoxy and a carboxamido group, optionally substituted with one or two lower alkyl radicals, and from among naphthalene derivatives chosen from the group consisting of the compounds of formula in which A is a free, etherified or esterified hydroxyl Z is defined as above and p is an integer varying from 1 to 3 and those of formula in which A, Z and p are defined as above Ar' is a mono- or bicyclic aromatic radical chosen from the group consisting of - the benzene derivatives of formula in which Y represents hydrogen, a halogen, an alkylenedioxy, a hydroxyl, a lower alkyl, an acyloxy derived from an organic carboxylic acid, a lower alkyl, a lower alkyl substituted with a (lower) alkylcarbonyl radical, an oxoalkyl chain of formula CO(CH2)m-CH3 in which m represents an integer ranging from 1 to 4 and a hydroxyalkyl chain of formula CHOH-(CH2)m'-CH3 in which m' represents an integer ranging from 1 to 4, - naphthalene derivatives chosen from the group consisting of the derivatives of formula in which Y is defined as above and n is an integer varying from 1 to 3 - and the derivatives of formula in which Y is defined as above and n is an integer varying from 1 to 3 R is a hydrogen, a hydroxyl, the oxygen of a carbonyl function or a lower alkyl radical R1 is hydrogen or a lower alkyl radical. These compounds are used as an active principle for antihypertensive, diuretic and platelet aggregation-inhibitory medicaments.