发明名称 |
ORGANOPHOSPHORUS HMG-COA REDUCTASE INHIBITORS, AND PHARMACEUTICAL COMPOSITIONS |
摘要 |
Compounds which are useful as inhibitors of cholesterol biosynthesis and thus as hypocholesterolemic agents are provided which have the structure <IMAGE> wherein R is OH, or salts thereof or lower alkoxy; R<x> is H or alkyl; X is -CH2-,-CH2-CH2-,-CH=CH-, -C IDENTICAL C-, -CH2CH2CH2- or -CH2O- (where O is linked to Z); Z is a hydrophobic anchor, such as <IMAGE> wherein the dotted lines represent optional double bonds. New intermediates used in preparing the above compounds, pharmaceutical compositions containing such compounds and a method for using such compounds to inhibit cholesterol biosynthesis are also provided. |
申请公布号 |
NZ224734(A) |
申请公布日期 |
1991.04.26 |
申请号 |
NZ19880224734 |
申请日期 |
1988.05.20 |
申请人 |
E R SQUIBB & SONS INC |
发明人 |
SOFIA, MICHAEL JOSEPH;KARANEWSKY, DONALD STEVEN;BADIA, MICHAEL CHRISTOPHER;BILLER, SCOTT ADAMS;GORDON, ERIC MICHAEL |
分类号 |
C07F9/42;A61K;A61K31/66;A61K31/675;A61K33/42;A61P3/06;A61P9/10;A61P43/00;C07F;C07F9/30;C07F9/32;C07F9/36;C07F9/40;C07F9/44;C07F9/547;C07F9/572;C07F9/6503;C07F9/6506;C07F9/655;C07F9/6553;C07F9/6558;C12N9/99 |
主分类号 |
C07F9/42 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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