PYRIMIDINES

摘要

Pyrimidine compounds of the formula in which one of the radicals R1, R2 and R3 is an optionally halogen- or hydroxyl-substituted aliphatic hydrocarbon radical or a cycloaliphatic or araliphatic hydrocarbon radical, the second of the radicals R1, R2 and R3 and the radical R4 are each, independently of one another, halogen, acyl, an aromatic hydrocarbon radical, optionally esterified or amidated carboxyl, cyano, SO3H, PO2H2, PO3H2, 5-tetrazolyl, optionally substituted sulphamoyl, acylamino or -Z1R' in which Z1 is a bond or O, S(O)m or N(R), R' is hydrogen or an aliphatic hydrocarbon radical which is optionally interrupted by O or S(O)m and is optionally substituted by halogen, hydroxyl, optionally substituted amino or optionally esterified or amidated carboxyl, R is hydrogen or an aliphatic hydrocarbon radical and m is in each case 0, 1 or 2, and the third of the radicals R1, R2 and R3 is the group of the formula in which Z2 is alkylene, O, S(O)m or N(R), R5 is carboxyl, halogenoalkanesulphonylamino, SO3H, PO2H2, PO3H2 or 5-tetrazolyl, R is hydrogen or an aliphatic hydrocarbon radical, m is 0, 1 or 2, and the rings A and B are, independently of one another, substituted optionally by halogen, an aliphatic hydrocarbon radical which is optionally interrupted by O and is optionally substituted by hydroxyl or halogen, or are substituted optionally by an aliphatic alcohol etherified hydroxyl, optionally esterified or amidated carboxyl or 5-tetrazolyl, and optionally tautomers thereof, in each case in free form or in salt form, can be prepared in a manner known per se and can be used, for example, as active substances in pharmaceutical compositions.