| 发明名称 |
CYTOTOXIC DRUG CONJUGATES |
| 摘要 |
Conjugates of antibodies and cytotoxic methotrexate drugs make use of linkers between the drug and antibody which are simple organic groups, wherein the link to the antibody is an acyl group and the link to the drug is an alkylidene hydrazide. |
| 申请公布号 |
ZA8905909(B) |
申请公布日期 |
1991.04.24 |
| 申请号 |
ZA19890005909 |
申请日期 |
1989.08.02 |
| 申请人 |
ELI LILLY AND COMPANY |
发明人 |
DAVID ARTHUR JOHNSON;BENNETT COLEMAN LAGUZZA;WILLIAM LEONARD SCOTT |
| 分类号 |
C12P21/08;A61K39/395;A61K47/48;A61P35/00;C07D475/08;C07K1/113;C07K14/00;C07K14/705;C07K16/00;C07K19/00;C12R1/91 |
主分类号 |
C12P21/08 |
| 代理机构 |
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代理人 |
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| 主权项 |
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| 地址 |
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